Uptake of 99mTc-HER-2 was also observed in nodal and distant metastatic lesions in multiple pelvic bones and lungs of a HER2 IHC positive patient with excellent conspicuity to background. Metastatic disease was confirmed with CT scan.
Patient: Male, 75 years old, chest x-ray showed lung shadow. CT scan confirmed multiple lesions. Biopsy confirmed squamous cell carcinoma, a lower left lobe lung hilar tumour, 44 x 48 mm is size with multiple metastases, nodal and distant. 99mTc-NM-01 scan results had uptake in primary tumour and multiple metastatic lesions, a strong positive image. PD-L1 IHC likely understated PD-L1 expression for this patient, PD-L1 treatment prognosis for such a patient is expected to be favourable, though further investigation is required.☯
Reference:- Quigley, Czech, Sendt, Notni 2021, “PET/CT imaging of pancreatic carcinoma targeting the “cancer integrin αvβ6″,European Journal of Nuclear Medicine and Molecular Imaging
While beta-emitting [90Y] PSA-mAb (labelled hu5A10 above) had a more immediate effect on tumour volume, treatment with [225Ac]PSA-mAb resulted in sustained tumour suppression and provided a significant increase in median survival time. The faster response time seen in Yttrium-90 treatment could be attributed to the difference between the chosen radionuclides in half-life and path length. demonstrates a stable humanised antibody, without signs of degradation and aggregation.